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Image Search Results
Journal: Cell Death Discovery
Article Title: Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b
doi: 10.1038/s41420-024-01955-y
Figure Lengend Snippet: A RB1 mutation rates by DNA sequence data in blood samples from PD (n = 189), AD (n = 33), HD (n = 69), and ALS (n = 75) patients from the Guangzhou KingMed Diagnostics Group Co. B Detailed information of the six mutation sites in neurodegenerative patients. C The detailed frequencies of the six mutation sites in neurodegenerative patients, normal Eastern Asian population, and frequency in the ALAF project from NCBI. PD Parkinson’s disease, AD Alzheimer’s disease, HD Huntington’s disease, ALS amyotrophic lateral sclerosis; -: no data. (Fisher’s exact test; *** P < 0.001).
Article Snippet: To determine the relationship between RB1 mutations and neurodegenerative disease, we calculated the RB1 mutation rates of PD (189 blood samples), AD (33 blood samples), HD (69 blood samples), and ALS (75 blood samples) using
Techniques: Mutagenesis, Sequencing